‘???? ???’ ???? ????[???? ????]
... ??? ????????, 2? ???? ... ??? ??? ???? COX ??? ??? ?? ??? ... ???? ?? ?? ?? ? 2??’ ()??? ‘????? ???’ ...
- 2024-11-24
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... ??? ????????, 2? ???? ... ??? ??? ???? COX ??? ??? ?? ??? ... ???? ?? ?? ?? ? 2??’ ()??? ‘????? ???’ ...
... ??? ??? ??(HO-1, Nrf2) ??? ?????? ?? ... ?? ?? ??(????(NO), COX-2 ?)? ??? ??(????, IL-31, TNF-α) ??? ????? ?? ????.???? ...
... ???)? 2017? 7??? 2019? 10??? ?? 7? ... ?????) ?? ??? 2??, 7??? ??? ?? ... ???? ?? ??? ??? cox ?? ?? ????? ?? ??? ?? ...
... ???? ??? 12? ??? ‘?? ... 1(COX-1)’ ??? ??? ... 2(COX-2)’ ??? ?? ??? ??? ??? ??? ? ???. ?? ?? ?????? ??????? ...
... ???. ???? PD-1, COX2 ?? ???? ... PD-1 ???????? COX2? ???? ??? ????? ???? ??????? ????. ? ?? 40%?? ???? ??? ????, ...
... 6?? ???? ?????, 2003??? ??? ??? 7?? ... ??? ?? ?? ??? COX-2 ???? ??? ? ???? ?? ?? ?? ??? ? ?? ??? ?? ???? ...
... ?????? ????. 1912? ??? ??? ?? ?? ? ... ????? ?? ?? ?? ?29? ?? ??????? ???? ??? ??(James M. Cox)? ?????? ??? ...
... ??? ?? ???? 2~3? 1~2?? ????? ??? ... ??? ???? ???? ‘Cox2’? ??? 78%? ????? ?? ??? 2004? ???? ??? ? ??. ???? ...
... ?????? ??? ??? ???? ??-2(COX-2) ??? ??? ??? ????? ?? ??-1(COX-1) ???? ??? ??? ??? ???? ???, ????, ??, ???? ...
... ? ??? ????. 11?29~12?1? ??? ????? ?? ... ? ??? ?? ??-2(COX-2,?? ??? ??? ??? ???? ??)? ????? ?????? ??·?? ??? ...