?????, ‘???’ ??? ?? ?? ??? ???

??1
?? 2019? 2? 26? 16? 58?

???: ?

???: ?

?“??? ??? ??? ??? ??? ??”

?? ???? ??? ??, ??? ??, ??? ??(????=?????) ? ??1

?????? ??????? ??? ??(?????? ???), ?????? ??? ??, ???????? ??? ??? ??? ???? ?? ???? ???? ???? ??? ???? ?????? ??? ????? 26? ???.

?? ???? ???? ??? ? ???? ???? ??? ??? ??? ?? ??? ?? ?? ??? ???.

???? ICSBP(Interferon Consensus Sequence-binding Protein)?? ???? ????????(TGF-β)? ????? ??? ??? ??? ??, ???? ??? ????? ?? ????.

??? ‘TGF-β’? ??? ??? ????? ???? ???? ?????? ??? ??? ??? ????? ?? ?? ?? ???? ?? ??? ???? ???? ???.

??, ???? ??? ????? ?? ??? ???? ICSBP ??? ???? TGF-βRI? ??? ???? ???? ?? ?? ???? ????.

??? ??? “?? ????? ?????? ???? ?? ??? ??????, ??? ??? ??? ??? ???? ??? ??? ????”? ???.

(??=??1)