??? ?????? ??
??? ????? ??????(?? ???, ?? ??)? ???? ‘ORM-5029’? ??? 1? ??? ?? ? ?? ??? ????? 1? ???.
ORM-5029? ??? ???? ? ???, ?? ??? ??? ???(TPD, targeted protein degrader, ???)? ADC(antibody drug conjugate)??? ??? ???? TPD2(Dual-Precision Targeted Protein Degradation) ??? ??? ??? ????. TPD2 ??? ??? ??? ??? ???? ?? ??? ?? ?? ???? ?? GSPT1?? ????? ????? ????. ORM-5029? HER2 ?? ??? ??? ????? GSPT1 ??? ???? ??? ????????.
?? ?? ??? ??? ? ?? HER2 ?????? ????? ???? ?? ??? ?? 80??? ???? ??. ??? ????? ?????? ????? ??? ?????? ???? UCLA, MD ???, Memorial Sloan and Kettering, ?? ?? ? ? 8? ?? ?????? ??? ????.
?????? ??? ?? ??? ???? ?? ??? ? ? 30%? ????? ????. ACS? ?? ??? ????? ???? ??? 28?7850?? ?? ??? ??? ? ??.
??? ????? ?????? CMO
??? ?? ?? 4? ?????(AACR) 2022? ???? ?? ORM-5029? ?? ??? ????. ?? ??? HER2 ?? ????? ?? ????(Kadcyla)? ???(Enhertu) ?? ORM-5029? ? 100? ??? ??? ????. ???? ????? ?????? ?? ????? ??? ??? ???.
??? ?? hongeunsim@donga.com