????????? ??? ??? ??? ???? ?????? ????????(G-7)?? ??? ????? ????? ????? 99%? ?? ???? ??? ??? ????? ???? ????. ? ?? ????? ?? ????? ???? '??? ????(Nature Genetics)'6??? ????? ????.

???? ???????? ?? ??? ???? ?? ?? ???? ?? ??? ??? ?????? ?? ????? ??? ???? ??? ?? ??? ?? ???? ????.

?? 1997? ???? ?? ??? ??? ??? '??'? 0.2%? ???? ?? ?????? ?? 99.8%? ????.

?? ????? ??? ????? ??? ??? ? ??(???)? ?? ????? '???'?? ???? ???(tag)? ???? ?????(?? '??? : methylation'??? ?) ???? ?????? ??? '???'? ???? ??(?? '????:demethylation??? ?)? ???? ??? ???? ??. ??? ?? ???? ???? ?? ?????? ??? '????'? ???? ?? '???'? ???? ??? ?? ??? ?? ???? ????? ???? ??? ?? ??? ?? ??? ???? ????.

??? ? ?? ??? ??? ??? ???? ???? ?????? ??? ?????? ???? ????? ??? ?? ? ??? ??? ????? ????

???lkmhan@donga.com